Ablation of TrkB from Enkephalinergic Precursor-Derived Cerebellar Granule Cells Generates Ataxia

In ataxia disorders, motor incoordination (ataxia) is primarily linked to the dysfunction and degeneration of cerebellar Purkinje cells (PCs). In spinocerebellar ataxia 6 (SCA6), for example, decreased BDNF–TrkB signalling appears to contribute to PC dysfunction and ataxia. However, abnormal BDNF–Tr...

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Hauptverfasser:	Elena Eliseeva, Mohd Yaseen Malik, Liliana Minichiello
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-08-01
Schriftenreihe:	Biology
Schlagworte:	ataxia cerebellar granule cells (GCs) TrkB BDNF–TrkB signalling enkephalinergic GC subset
Online-Zugang:	https://www.mdpi.com/2079-7737/13/8/637
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