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Establishment of a selective evaluation method for DPP4 inhibitors based on recombinant human DPP8 and DPP9 proteins

Dipeptidyl peptidase 4 (DPP4) is recognised as an attractive anti-diabetic drug target, and several DPP4 inhibitors are already on the market. As members of the same gene family, dipeptidyl peptidase 8 (DPP8) and dipeptidyl peptidase 9 (DPP9) share high sequence and structural homology as well as fu...

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Príomhchruthaitheoirí: Jinglong Liu, Yi Huan, Caina Li, Minzhi Liu, Zhufang Shen
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2014-04-01
Sraith:Acta Pharmaceutica Sinica B
Ábhair:
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211383513001123
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