The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-<i>O</i>-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet. Pharmacokinetic parameters of donepezil and its active metabolite 6-<i>O</i>-desmet...

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Bibliografiske detaljer

Principais autores:	Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2021-04-01
Serier:	Molecules
Fag:	6-<i>O</i>-desmethyldonepezil dextran sodium sulfate donepezil electrogastrography experimental pigs gastric myoelectric activity
Online adgang:	https://www.mdpi.com/1420-3049/26/8/2160
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