Enhancing cardiomyocyte reprogramming efficiency by targeting cellular senescence is mediated via Rb1 gene

Abstract Introduction Direct reprogramming of fibroblasts into cardiomyocytes by overexpressing cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) is a promising way for cardiac repair, however, the low reprogramming efficiency remains a significant challenge. Cellular senescence, an irrever...

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Autori principali:	Juntao Fang, Qiangbing Yang, Renée G. C. Maas, Pieter Vader, Michal Mokry, Noortje A. M. van den Dungen, Li Qian, Junjie Xiao, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-12-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Direct cardiac reprogramming Senescence RB1
Accesso online:	https://doi.org/10.1186/s13287-025-04776-7
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