Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions

Abstract Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and efficient targeting of these receptors are lacking. The development of new P2...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2022-10-01
Serija:	Journal of Neuroinflammation
Teme:	P2X7 Nanobodies Ischemic stroke Nanomedicine Cerebrovascular disease
Online dostop:	https://doi.org/10.1186/s12974-022-02601-z
Oznake:	Označite Brez oznak, prvi označite!