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Nitrofuranyl derivatives as promising antitubercular agents: Structural insights and drug discovery perspectives

The emergence of MDR (multidrug-resistant) and XDR (extensively drug-resistant) variants of Mycobacterium tuberculosis has contributed to the universal resurgence of tuberculosis (TB). Nitrofuran-based compounds, traditionally used as antibacterial agents, have recently gained attention for their po...

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Principais autores: Afreen N, Smriti Sharma
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-04-01
coleção:European Journal of Medicinal Chemistry Reports
Assuntos:
Nitrofuran derivatives
Antitubercular agents
Multidrug-resistant tuberculosis (MDR-TB)
Structure–activity relationship (SAR)
Mycobacterium tuberculosis
Drug repurposing
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2772417425000706
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