Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury

Abstract Background Neonatal encephalopathy following hypoxia–ischemia (HI) is a leading cause of childhood death and morbidity. Hypothermia (HT), the only available but obligatory therapy is limited due to a short therapeutic window and limited efficacy. An adjuvant therapy overcoming limitations o...

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Bibliografiska uppgifter

Huvudupphov:	Nicole Labusek, Parnian Ghari, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Martin Hadamitzky, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel, Josephine Herz
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2023-11-01
Serie:	Journal of Neuroinflammation
Ämnen:	Neonatal hypoxia–ischemia Neonatal encephalopathy Hypothermia Mesenchymal stem/stromal cells Extracellular vesicles Long-term neurodevelopmental deficits
Länkar:	https://doi.org/10.1186/s12974-023-02961-0
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