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Taste-Masked Flucloxacillin Powder Part 2: Formulation Optimisation Using the Mixture Design Approach and Storage Stability

Flucloxacillin is prescribed to treat skin infections but its highly bitter taste is poorly tolerated in children. This work describes the application of the D-optimal mixture experimental design to identify the optimal component ratio of flucloxacillin, Eudragit EPO and palmitic acid to prepare flu...

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Principais autores: Okhee Yoo, Sam Salman, Britta S. von Ungern-Sternberg, Lee Yong Lim
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-08-01
coleção:Pharmaceuticals
Assuntos:
flucloxacillin
Eudragit EPO
palmitic acid
taste-masked microparticles
mixture design
paediatric formulation
Acesso em linha:https://www.mdpi.com/1424-8247/16/8/1179
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