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Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

XMAP215/Stu2/Alp14 proteins accelerate microtubule plus-end polymerization by recruiting tubulins via arrays of tumor overexpressed gene (TOG) domains, yet their mechanism remains unknown. Here, we describe the biochemical and structural basis for TOG arrays in recruiting and polymerizing tubulins....

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Main Authors: Stanley Nithianantham, Brian D Cook, Madeleine Beans, Fei Guo, Fred Chang, Jawdat Al-Bassam
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
x-ray
tubulin
microtubule
TOG domain
XMAP215
Alp14
Online Access:https://elifesciences.org/articles/38922
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