Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector func...

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Autori principali:	Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2018-06-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-018-04719-2
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