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Nongenomic Mechanisms of PTEN Regulation

A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cel...

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Autors principals: Jimmie E. Fata, Shawon Debnath, Edmund C. Jenkins, Marcia V. Fournier
Format: Artigo
Idioma:Inglês
Publicat: Wiley 2012-01-01
Col·lecció:International Journal of Cell Biology
Accés en línia:http://dx.doi.org/10.1155/2012/379685
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