White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

We postulate that myelin injury contributes to cholesterol release from myelin and cholesterol dysmetabolism which contributes to Abeta dysmetabolism, and combined with genetic and AD risk factors, leads to increased Abeta and amyloid plaques. Increased Abeta damages myelin to form a vicious injury...

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Principais autores:	Frank R. Sharp, Charles S. DeCarli, Lee-Way Jin, Xinhua Zhan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-02-01
coleção:	Frontiers in Aging Neuroscience
Assuntos:	white matter myelin cholesterol APOE Abeta Alzheimer’s disease
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2023.1096206/full
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