Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular expression pattern and release toxic factors that contribute to neurodegeneration and microglial activation. We and others identified a dysregulated inflammatory miRNA profile in ALS patients and in mice models suggest...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Marta Barbosa, Cátia Gomes, Catarina Sequeira, Joana Gonçalves-Ribeiro, Carolina Campos Pina, Luís A. Carvalho, Rui Moreira, Sandra H. Vaz, Ana Rita Vaz, Dora Brites
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-04-01
Schriftenreihe:	Frontiers in Cell and Developmental Biology
Schlagworte:	amyotrophic lateral sclerosis astrocyte-microglia communication astrocyte-motor neuron crosstalk calcium signaling aberrancies glycoursodeoxycholic acid reactive astrocytes
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcell.2021.634355/full
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