Zinc <i>N</i>,<i>N</i>-bis(2-picolyl)amine Chelates Show Substitution-Dependent Cleavage of Phosphodiesters in Models as Well as of PNAzyme-RNA Bulges

PNAzymes are a group of artificial enzymes which show promising results in selective and efficient cleavage of RNA targets. In the present study, we introduce a series of metal chelating groups based on <i>N</i>,<i>N</i>-bis(2-picolyl) groups (parent, 6-methyl and 6-amino substituted) as the active...

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Autors principals:	Søren W. Svenningsen, Olivia Luige, Zeyed Abdulkarim, Roger Strömberg, Nicholas H. Williams
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-05-01
Col·lecció:	Molecules
Matèries:	PNAzyme metal chelate RNA substrate RNA bulge phosphodiester cleavage
Accés en línia:	https://www.mdpi.com/1420-3049/29/9/2123
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