Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study

Abstract Background Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-formylmethionine is associated with increases in metabolomic shift-rela...

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Egile Nagusiak:	Martin Ingi Sigurdsson, Hirotada Kobayashi, Karin Amrein, Kiichi Nakahira, Angela J. Rogers, Mayra Pinilla-Vera, Rebecca M. Baron, Laura E. Fredenburgh, Jessica A. Lasky-Su, Kenneth B. Christopher
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2022-10-01
Saila:	Critical Care
Gaiak:	Metabolomics N-formylmethionine Critical illness Acylcarnitine Metabolic shift Pentose phosphate pathway
Sarrera elektronikoa:	https://doi.org/10.1186/s13054-022-04174-y
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