Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Abstract Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decreasing clinical efficacy in treating C. difficile in...

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Egile Nagusiak:	Abiola O. Olaitan, Chetna Dureja, Madison A. Youngblom, Madeline A. Topf, Wan-Jou Shen, Anne J. Gonzales-Luna, Aditi Deshpande, Kirk E. Hevener, Jane Freeman, Mark H. Wilcox, Kelli L. Palmer, Kevin W. Garey, Caitlin S. Pepperell, Julian G. Hurdle
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2023-07-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-023-39429-x
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