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Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

para-Aminosalicylic acid (PAS) is a second-line anti-tubercular drug that is used for the treatment of drug-resistant tuberculosis (TB). PAS efficacy in the treatment of TB is limited by its lower potency against Mycobacterium tuberculosis relative to many other drugs in the TB treatment arsenal. It...

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Principais autores: Michael D. Howe, Shannon L. Kordus, Malcolm S. Cole, Allison A. Bauman, Courtney C. Aldrich, Anthony D. Baughn, Yusuke Minato
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-11-01
Serier:Frontiers in Cellular and Infection Microbiology
Fag:
Mycobacterium tuberculosis
anti-folate drug
para-aminosalicylic acid
methionine
para-aminobenzoic acid
biotin
Online adgang:https://www.frontiersin.org/article/10.3389/fcimb.2018.00399/full
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