Design, synthesis, biological assessments and computational studies of 3-substituted phenyl quinazolinone derivatives as promising anti-cancer agents

Abstract A new series of 3-substituted phenyl quinazolinone derivatives were designed and synthesized as anti-cancer agents. The most potent derivative with IC50 values of 12.84 ± 0.84 and 10.90 ± 0.84 µM against MCF-7 and SW480 cell lines was comparable to Cisplatin and Erlotinib as positive contro...

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Principais autores:	Maryam Moghtader Mansouri, Leila Emami, Zahra Rezaei, Soghra Khabnadideh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-05-01
coleção:	BMC Chemistry
Assuntos:	Quinazoline Hydrazine MTT Cell cycle Apoptosis Molecular dynamic simulation
Acesso em linha:	https://doi.org/10.1186/s13065-025-01492-4
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