An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets

Abstract Background Inclusion bodies (IBs) are well-known subcellular structures in bacteria where protein aggregates are collected. Various methods have probed their structure, but single-cell spectroscopy remains challenging. Atomic Force Microscopy-based Infrared Spectroscopy (AFM-IR) is a novel...

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Autori principali:	Wouter Duverger, Grigoria Tsaka, Ladan Khodaparast, Laleh Khodaparast, Nikolaos Louros, Frederic Rousseau, Joost Schymkowitz
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-07-01
Serie:	Journal of Nanobiotechnology
Soggetti:	AFM-IR Image analysis Protein aggregation Escherichia coli Infrared spectroscopy
Accesso online:	https://doi.org/10.1186/s12951-024-02674-3
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