Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling

Abstract Background Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of adenosine 5’ triphosphate (ATP) by the membrane-embedded enzymes CD39 and...

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Autors principals:	Taha Kelestemur, Zoltán H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig, György Haskó
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-07-01
Col·lecció:	Respiratory Research
Matèries:	CD39 CD73 A2BR Adenosine Acute lung injury Trauma hemorrhagic shock
Accés en línia:	https://doi.org/10.1186/s12931-023-02486-3
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