The Interplay of Metabolism, Epigenome and Transcriptome Integrity, and the Emerging Role of NLRP7 in Early Human Embryo Arrest

Background/Objectives: Early embryonic arrest during the cleavage stage (days 2–4) accounts for a substantial proportion of developmental failure in in vitro fertilization. This phenomenon remains poorly understood at the molecular level, even in chromosomally normal embryos identified by preimplant...

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Hlavní autoři:	Radoslav Rangelov, Krassimira Todorova, Soren Hayrabedyan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2026-03-01
Edice:	Applied Sciences
Témata:	embryonic arrest cleavage-stage embryos maternal-to-zygotic transition zygotic genome activation metabolic epigenetics intron retention
On-line přístup:	https://www.mdpi.com/2076-3417/16/7/3150
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