An unexpected effect of TNF-α on F508del-CFTR maturation and function [v1; ref status: indexed, http://f1000r.es/5jf]

Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which encodes a cAMP-dependent Cl- channel. The most frequent mutation, F508del, leads to the synthesis of a prematurely degraded, otherwise partially function...

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Principais autores:	Sara Bitam, Iwona Pranke, Monika Hollenhorst, Nathalie Servel, Christelle Moquereau, Danielle Tondelier, Aurélie Hatton, Valérie Urbach, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter, Aleksander Edelman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	F1000 Research Ltd 2015-07-01
Colecção:	F1000Research
Assuntos:	Cell Signaling Control of Gene Expression Genomics
Acesso em linha:	http://f1000research.com/articles/4-218/v1
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