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Unraveling novel mutation patterns and morphological variations in two dalbavancin-resistant MRSA strains in Austria using whole genome sequencing and transmission electron microscopy

Abstract Background The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains resistant to non-beta-lactam antimicrobials poses a significant challenge in treating severe MRSA bloodstream infections. This study explores resistance development and mechanisms in MRSA isol...

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Main Authors: Julian Frederic Hotz, Moritz Staudacher, Katharina Schefberger, Kathrin Spettel, Katharina Schmid, Richard Kriz, Lisa Schneider, Jürgen Benjamin Hagemann, Norbert Cyran, Katy Schmidt, Peter Starzengruber, Felix Lötsch, Amelie Leutzendorff, Simon Daller, Michael Ramharter, Heinz Burgmann, Heimo Lagler
Format: Artigo
Language:Inglês
Published: BMC 2024-09-01
Series:BMC Infectious Diseases
Subjects:
MRSA
Dalbavancin
Whole genome sequencing
Antimicrobial resistance
Linezolid
Daptomycin
Online Access:https://doi.org/10.1186/s12879-024-09797-w
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