Overexpression of the major facilitator superfamily efflux pump gene nfa56470 mediates ciprofloxacin resistance in Nocardia farcinica

ObjectivesTo explore the molecular basis of ciprofloxacin resistance in N. farcinica, providing a scientific basis for clinical antibiotic use and controlling the spread of resistant strains.MethodsWe analyzed 20 N. farcinica strains. The quinolone resistance-determining regions (QRDRs) of gyrA and...

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Autori principali:	Chenchen Si, Qiang Jiang, Poshi Xu, Tao Li, Shixuan Hua, Zhenjun Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-12-01
Serie:	Frontiers in Cellular and Infection Microbiology
Soggetti:	Nocardia farcinica resistance mechanisms ciprofloxacin efflux pump efflux pump inhibitors major facilitator superfamily
Accesso online:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1708290/full
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