Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors

Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission can be an effective therapeutic strategy toward AD. Herein, we report for the f...

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Autors principals:	Catarina Oliveira, Fernando Cagide, José Teixeira, Ricardo Amorim, Lisa Sequeira, Francesco Mesiti, Tiago Silva, Jorge Garrido, Fernando Remião, Santiago Vilar, Eugenio Uriarte, Paulo J. Oliveira, Fernanda Borges
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2018-04-01
Col·lecció:	Frontiers in Chemistry
Matèries:	hydroxybenzoic acids oxidative stress mitochondria-targeted antioxidants cholinesterase inhibitors acetyl and butyrylcholinesterase
Accés en línia:	http://journal.frontiersin.org/article/10.3389/fchem.2018.00126/full
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