Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery

Understanding the many factors affecting the circulation of cerebrospinal fluid (CSF) is important for the treatment of neurological diseases, especially when considering macromolecular pharmaceuticals designed to be delivered directly into the ventricles of the brain. CSF production, pressure, flow...

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Hlavní autoři:	Herbert H. Engelhard, Olivier Balédent, Matthew T. Borzage, Lydia Andrews-Jones, Thomas M. Feldsien, Didier R. Lefebvre
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-05-01
Edice:	Frontiers in Drug Delivery
Témata:	adeno-associated virus brain, cerebrospinal fluid choroid plexus intraventricular drug delivery Ommaya reservoir phase-contrast magnetic resonance imaging
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fddev.2026.1735474/full
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