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A new analysis approach of epidermal growth factor receptor pathway activation patterns provides insights into cetuximab resistance mechanisms in head and neck cancer

<p>Abstract</p> <p>The pathways downstream of the epidermal growth factor receptor (EGFR) have often been implicated to play crucial roles in the development and progression of various cancer types. Different authors have proposed models in cell lines in which they study the modes of pathway activit...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: von der Heyde Silvia, Beissbarth Tim
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2012-05-01
Schriftenreihe:BMC Medicine
Schlagworte:
HNSCC
EGFR
cetuximab
drug resistance
matrix factorization
GSEA
pathway signature
Online-Zugang:http://www.biomedcentral.com/1741-7015/10/43
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