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Bayesian PBPK modeling using R/Stan/Torsten and Julia/SciML/Turing.Jl

Abstract Physiologically‐based pharmacokinetic (PBPK) models are mechanistic models that are built based on an investigator's prior knowledge of the in vivo system of interest. Bayesian inference incorporates an investigator's prior knowledge of parameters while using the data to update this knowled...

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Autori principali: Ahmed Elmokadem, Yi Zhang, Timothy Knab, Eric Jordie, William R. Gillespie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2023-03-01
Serie:CPT: Pharmacometrics & Systems Pharmacology
Accesso online:https://doi.org/10.1002/psp4.12926
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