Nuclear Fragility in Radiation-Induced Senescence: Blebs and Tubes Visualized by 3D Electron Microscopy

Irreparable DNA damage following ionizing radiation (IR) triggers prolonged DNA damage response and induces premature senescence. Cellular senescence is a permanent state of cell-cycle arrest characterized by chromatin restructuring, altered nuclear morphology and acquisition of secretory phenotype,...

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Principais autores:	Benjamin M. Freyter, Mutaz A. Abd Al-razaq, Anna Isermann, Anne Dietz, Omid Azimzadeh, Liesbeth Hekking, Maria Gomolka, Claudia E. Rübe
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-01-01
coleção:	Cells
Assuntos:	cellular senescence ionizing radiation radiation-induced senescence chromatin reorganization nuclear blebbing transmission electron microscopy (TEM)
Acesso em linha:	https://www.mdpi.com/2073-4409/11/2/273
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