Enhanced thermal stability enables human mismatch-specific thymine-DNA glycosylase to catalyse futile DNA repair.

Human thymine-DNA glycosylase (TDG) excises T mispaired with G in a CpG context to initiate the base excision repair (BER) pathway. TDG is also involved in epigenetic regulation of gene expression by participating in active DNA demethylation. Here we demonstrate that under extended incubation time t...

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Principais autores:	Diana Manapkyzy, Botagoz Joldybayeva, Alexander A Ishchenko, Bakhyt T Matkarimov, Dmitry O Zharkov, Sabira Taipakova, Murat K Saparbaev
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2024-01-01
coleção:	PLoS ONE
Acesso em linha:	https://doi.org/10.1371/journal.pone.0304818
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