Single-Cell Hypertrophy Promotes Contractile Function of Cultured Human Airway Smooth Muscle Cells via Piezo1 and YAP Auto-Regulation

Severe asthma is characterized by increased cell volume (hypertrophy) and enhanced contractile function (hyperresponsiveness) of the airway smooth muscle cells (ASMCs). The causative relationship and underlying regulatory mechanisms between them, however, have remained unclear. Here, we manipulated...

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Auteurs principaux:	Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Yan Pan, Jingjing Li, Lei Liu, Mingzhi Luo, Linhong Deng
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2024-10-01
Collection:	Cells
Sujets:	ASMC hypertrophy contractile function cell volume membrane tension Piezo1 YAP
Accès en ligne:	https://www.mdpi.com/2073-4409/13/20/1697
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