Construction of tetravalent bispecific Tandab (CD3/BCMA)-secreting human umbilical cord mesenchymal stem cells and its efficiency in the treatment of multiple myeloma

Abstract Background Highly efficient targeted therapy is urgently needed for multiple myeloma (MM). Mesenchymal stem cells (MSCs) are an attractive candidate of cell-based, targeted therapy due to their inherent tumor tropism. However, there is still no MSCs-based tandem diabody for treating MM. Met...

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Detalhes bibliográficos

Principais autores:	Mengshang Xiong, Chunfang Kong, Yang Lu, Jiaojun Liu, Weirong Ding, Tingting Zhang, Wei Zuo, Lixia Cao, Qiling Lu, Anna Li, Chaoyu Li, Liting Ding, Yutao Yan, Bo Ke, Caishui Wan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
coleção:	Stem Cell Research & Therapy
Assuntos:	MSCs T-cell bispecific antibodies CD3 BCMA Multiple myeloma
Acesso em linha:	https://doi.org/10.1186/s13287-025-04212-w
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