PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels

The PI3K/AKT pathway, negatively regulated by PTEN, plays a paramount role in glucose metabolism regulation due to its activation by the insulin receptor signaling pathway. We generated a PTEN-KO mouse to evaluate the systemic effect of the overactivation of the PI3K/AKT pathway in insulin signaling...

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Κύριοι συγγραφείς:	Maria Crespo-Masip, Aurora Pérez-Gómez, Carla Guzmán, Sandra Rayego, Nuria Doladé, Alicia García-Carrasco, Ramiro Jover, José Manuel Valdivielso
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2022-02-01
Σειρά:	Frontiers in Endocrinology
Θέματα:	PI3K/AKT hypoinsulinemic hypoglycemia gluconeogenesis lipid metabolism glucose metabolism
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fendo.2022.850214/full
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