Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

ABSTRACT Neuroinflammation is a critical driver of epileptogenesis and cognitive dysfunction in epilepsy; however, targeted anti‐inflammatory therapies remain limited. In this study, we demonstrate that microglial GPR35 orchestrates neuroinflammatory epileptic networks through platelet‐derived growt...

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Hlavní autoři:	Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-04-01
Edice:	Advanced Science
Témata:	epileptogenesis GPR35 kynurenic acid neuroinflammation PDGFA
On-line přístup:	https://doi.org/10.1002/advs.202519642
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