Extra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells

Abstract Adeno-associated viral (AAV) vector suspensions produced in either human derived HEK cells or in Spodoptera frugiperda (Sf9) insect cells differ in terms of residual host cell components as well as species-specific post-translational modifications displayed on the AAV capsid proteins. Here...

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Principais autores:	Kirsten Bucher, Eduardo Rodríguez-Bocanegra, Bernd Wissinger, Torsten Strasser, Simon J. Clark, Andreas L. Birkenfeld, Dorothea Siegel-Axel, M. Dominik Fischer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-02-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-023-28830-7
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