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Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

The ubiquitin-proteasome system targets misfolded proteins for degradation. Since the accumulation of such proteins is potentially harmful for the cell, their prompt removal is important. E3 ubiquitin-protein ligases mediate substrate ubiquitination by bringing together the substrate with an E2 ubiq...

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Auteurs principaux: Wouter Boomsma, Sofie V. Nielsen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen, Lars Ellgaard
Format: Artigo
Langue:Inglês
Publié: PeerJ Inc. 2016-02-01
Collection:PeerJ
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Accès en ligne:https://peerj.com/articles/1725.pdf
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