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Practical identifiability analysis of a mechanistic model for the time to distant metastatic relapse and its application to renal cell carcinoma.

Distant metastasis-free survival (DMFS) curves are widely used in oncology. They are classically analyzed using the Kaplan-Meier estimator or agnostic statistical models from survival analysis. Here we report on a method to extract more information from DMFS curves using a mathematical model of prim...

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Bibliografische Detailangaben
Hauptverfasser: Arturo Álvarez-Arenas, Wilfried Souleyreau, Andrea Emanuelli, Lindsay S Cooley, Jean-Christophe Bernhard, Andreas Bikfalvi, Sebastien Benzekry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2022-08-01
Schriftenreihe:PLoS Computational Biology
Online-Zugang:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010444&type=printable
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