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ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts

Abstract Cellular response to protein misfolding underlies multiple diseases. Collagens are the most abundant vertebrate proteins, yet little is known about cellular response to misfolding of their procollagen precursors. Osteoblasts (OBs)—the cells that make bone—produce so much procollagen that it...

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Principais autores: Laura Gorrell, Elena Makareeva, Shakib Omari, Satoru Otsuru, Sergey Leikin
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley 2022-10-01
סדרה:Advanced Science
נושאים:
ATF5
cell stress
collagen
osteoblast
osteogenesis imperfecta
HSPA9/mt‐Hsp70/GRP75
גישה מקוונת:https://doi.org/10.1002/advs.202201273
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