Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells

Abstract Myeloid cells are highly heterogeneous and play key roles in establishing an immunosuppressive tumor microenvironment (TME), but the mechanisms controlling their differentiation remain unclear. Using orthotopic murine breast cancer models, we investigated how interleukin-1α (IL-1α) influenc...

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Detalles Bibliográficos

Principais autores:	Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa Armstrong, R. Michael Gower, Igor B. Roninson, Eugenia V. Broude, Mengqian Chen, Hao Ji, Chang-uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu, Jie Li, Gang Zhou, Hexin Chen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-01-01
Series:	npj Breast Cancer
Acceso en liña:	https://doi.org/10.1038/s41523-026-00890-8
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