Genome-wide CRISPR screens in primary human natural killer cells identify countermeasures against immunosuppressive environment

Abstract Natural killer (NK) cells are promising effectors for cancer immunotherapy, but their efficacy is limited by immunosuppressive tumor microenvironments. To uncover strategies for enhancing NK cell function, we establish a CRISPR loss-of-function screening platform for primary human NK cells...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Quoc Viet Nguyen, Yi-Jun Lan, Jason Cheng-Yu Chang, Hsin-An Shih, Jenifer Faustine, Cheng-Chieh Chen, Shu-Yu Ho, Ching-Wen Cheng, Tsu-Lan Chao, Steven Lin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-04-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-026-71895-x
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