Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Abstract Background TP53, encoding the tumor suppressor p53, is frequently mutated in various cancers, producing mutant p53 proteins (mutp53) which can exhibit neomorphic, gain-of-function properties. The latter transform p53 into an oncoprotein that promotes metastatic tumor progression via downstr...

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Autori principali:	Evangelos Pavlakis, Michelle Neumann, Nastasja Merle, Ronja Wieboldt, Michael Wanzel, Viviane Ponath, Elke Pogge von Strandmann, Sabrina Elmshäuser, Thorsten Stiewe
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-08-01
Serie:	Journal of Experimental & Clinical Cancer Research
Soggetti:	p53 Tumor suppressor gene Metastasis ENTPD5 Calnexin Calreticulin
Accesso online:	https://doi.org/10.1186/s13046-023-02785-z
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