Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer

Although immune-based therapies have revolutionized the management of cancer, novel approaches are urgently needed to improve their outcome. We investigated the role of endogenous steroids in the resistance to cancer immunotherapy, as these have strong immunomodulatory functions. Using a publicly av...

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Detalles Bibliográficos

Principais autores:	Hélène Poinot, Eloïse Dupuychaffray, Grégoire Arnoux, Montserrat Alvarez, Jérémie Tachet, Ounss Ezzar, Jonathan Moore, Olivia Bejuy, Eulalia Olesti, Gioele Visconti, Víctor González-Ruiz, Serge Rudaz, Jean-Christophe Tille, Clarissa D. Voegel, Patrycja Nowak-Sliwinska, Carole Bourquin, Aurélien Pommier
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2024-12-01
Series:	OncoImmunology
Assuntos:	Glucocorticoids HSD11B1 immunotherapy renal cancer steroidogenesis
Acceso en liña:	https://www.tandfonline.com/doi/10.1080/2162402X.2023.2286820
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