Osteocalcin ameliorates cognitive dysfunctions in a mouse model of Alzheimer’s Disease by reducing amyloid β burden and upregulating glycolysis in neuroglia

Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by the accumulation of amyloid β peptides (Aβ) and impaired glucose metabolism in the brain. Osteocalcin (OCN), an osteoblast-derived protein, has been shown to modulate brain functions but whether it has an...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Chang Shan, Deng Zhang, Dong-ni Ma, Yan-fang Hou, Qian-qian Zhuang, Yan-ling Gong, Li-hao Sun, Hong-yan Zhao, Bei Tao, Yu-ying Yang, Sheng-tian Li, Jian-min Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2023-02-01
Colecção:	Cell Death Discovery
Acesso em linha:	https://doi.org/10.1038/s41420-023-01343-y
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!