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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

Tropomyosin receptor kinase B (TrkB) signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and memory. The activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre- or postsynaptic TrkB resulting in the strengthening of s...

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Hlavní autoři: Xin Yang, Yu-Wen Alvin Huang, John Marshall
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer Medknow Publications 2025-03-01
Edice:Neural Regeneration Research
Témata:
angelman syndrome
autism
brain-derived neurotrophic factor
depression
neurodegenerative disorder
neurodevelopmental disorder
postsynaptic density protein-95
synaptic plasticity
trkb
On-line přístup:https://journals.lww.com/10.4103/NRR.NRR-D-23-02000
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