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Protective Effects of Interleukin‐1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion

Background Severe brain ischemia is associated with life‐threatening edema and inflammation. Interleukin‐1 is a crucial mediator of inflammation, and its blockade showed benefits in experimental stroke. We studied anakinra, a modified recombinant human interleukin‐1 receptor antagonist, in mouse mod...

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Автори: Nerea Chaparro‐Cabanillas, Alicia Aliena‐Valero, Jordi Pedragosa, Leire Pedrosa, Milagros Honores, Mercè Rossinyol‐Boladeres, Juan B. Salom, Ángel Chamorro, Juan I. Arostegui, Xabier Urra, Carles Justicia, Anna M. Planas
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2025-05-01
Серія:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Предмети:
anakinra
cytokines
edema
inflammation
ischemic stroke
malignant infarction
Онлайн доступ:https://www.ahajournals.org/doi/10.1161/JAHA.124.040474
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