Epigenetic potentiation of 5-fluorouracil by HDAC inhibitor quisinostat enhances antitumor effects in colorectal cancer

Abstract Background Histone deacetylase (HDAC) inhibitors have emerged as promising epigenetic therapeutics in cancer treatment; however, their clinical efficacy in solid tumors remains limited. Quisinostat is a potent pan-HDAC inhibitor with demonstrated anticancer activity in various malignancies....

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Bibliografiska uppgifter

Huvudupphov:	Gizem Calibasi-Kocal, Hasan Kurter, Eylem Doga Nartas, Ender Berat Ellidokuz, Yasemin Basbinar
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-10-01
Serie:	Cancer Cell International
Ämnen:	Colorectal cancer Histone deacetylase Histone deacetylase inhibitor Apoptosis Metastasis
Länkar:	https://doi.org/10.1186/s12935-025-03992-8
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