Synthesis, biological evaluation and in silico study of 4-(benzo[d]thiazole-2-yl) phenols based on 4-hydroxy coumarin as acetylcholinesterase inhibitors

Abstract Alzheimer’s disease, characterized by cognitive decline and memory loss, is associated with decreased acetylcholine levels due to acetylcholinesterase (AChE) activity. Compounds containing a coumarin heterocyclic core coupled with thiazole exhibit excellent acetylcholinesterase inhibitory a...

Descripció completa

Dades bibliogràfiques

Autors principals:	Bi Bi Fatemeh Mirjalili, Seyedeh Azita Fazeli Attar, Fereshteh Shiri
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-11-01
Col·lecció:	Scientific Reports
Matèries:	Coumarine heterocyclic Acetylcholinesterase inhibitors Alzheimer’s disease Molecular docking Molecular dynamic
Accés en línia:	https://doi.org/10.1038/s41598-024-74001-7
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!