The MHC-II Transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators

The activation of CD4+ T helper cells is strictly dependent on the presentation of antigenic peptides by MHC Class II molecules. MHC-II expression is primarily regulated at the transcriptional level by the AIR-1 gene product CIITA (Class II transactivator). Thus, CIITA plays a pivotal role in the tr...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Greta eForlani, Rawan eAbdallah, Roberto S Accolla, Giovanna eTosi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2013-08-01
coleção:	Frontiers in Microbiology
Assuntos:	CIITA restriction factors viral replication HTLV-1 Tax-1 HTLV-2 Tax-2
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00234/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!