Aza-BODIPY based carbonic anhydrase IX: Strategy to overcome hypoxia limitation in photodynamic therapy

Hypoxia caused by photodynamic therapy (PDT) is a major hurdle to cancer treatment since it can promote recurrence and progression by activating angiogenic factors, lowering therapeutic efficacy dramatically. In this work, AZB-I-CAIX2 was developed as a carbonic anhydrase IX (CAIX)-targeting NIR pho...

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Principais autores:	Thitima Pewklang, Kantapat Chansaenpak, Siti Nursyahirah Bakar, Rung-Yi Lai, Chin Siang Kue, Anyanee Kamkaew
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Chemistry
Assuntos:	aza-BODIPY PDT acetazolamide carbonic anhydrase IX (CA9) hypoxia
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fchem.2022.1015883/full
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