Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay
In Drosophila, ER-targeted mRNAs are degraded by Ire1-dependent pathway. Here the authors report that the fly mRNA binding protein Pumilio is phosphorylated by Ire1 and binds to Xbp1 mRNA, protecting it from the non-canonical endoribonuclease activity of Ire1.
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| Principais autores: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2022-03-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-022-29105-x |
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